ARNICA Montana FlowerExtract

• https://onlinelibrary.wiley.com/doi/epdf/10.1111/ics.12815

  Out of 380 natural plants and flowers. Arnica montana L. flower extract demonstrated the best effects. After 4weeks, 92% of the participants noticed an improvement in facial skin volume. As expected, the volume increase caused a significant improvement in smile line wrinkles (Figure 6b). None of the participants suffered any adverse reactions or side effects from the AFE.

• https://journals.lww.com/plasreconsurg/abstract/2007/07000/a_randomized,_controlled_comparison_between_arnica.39.aspxThis study suggests that both arnica and corticosteroids may be effective in reducing edema during the early postoperative period.

• https://www.tandfonline.com/doi/abs/10.1080/15569527.2020.1743998 our results demonstrated that Arnica montana reduced the UVB-induced inflammatory response as demonstrated by the reduction of ear edema, inhibition of myeloperoxidase activation, decrease of nuclear factor kappa B levels and reduction of proinflammatory cytokines levels, such as interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and interferon-gamma.

• https://pubmed.ncbi.nlm.nih.gov/36752313/ Expression levels of collagen were increased in the ARN and ARN + MC groups when compared with control and MC groups on Day 6, while expression of collagen III was enhanced in MC, ARN, and ARN + MC groups when compared with the control. The protocol combining microcurrent with topical application of ARN reduces the inflammatory process, increases myofibroblasts proliferation and decreases the presence of macrophages in the dermis during skin repair

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605207/ The topical application of an A. montana-containing gel demonstrated beneficial effects on experimental wound healing in an animal model32 and an A. montana-containing ointment improved pulsed-dye laser-induced bruising in human volunteers.33

• https://pubmed.ncbi.nlm.nih.gov/37541071/ The group treated with the plant extract at a concentration of 10% significantly increased FGF-2, VEGF-A expression, and collagen formation, which are important criteria for wound healing.

• https://pubmed.ncbi.nlm.nih.gov/27847336/ Many studies have shown that the extracts and some compounds isolated from this plant exhibit a broad spectrum of biological activities such as antioxidant, antitumor, anti-inflammatory, cytotoxic, and chelating activities, as well as insecticidal and phytotoxic activity.

• https://pubmed.ncbi.nlm.nih.gov/15490315/ Altogether, this study shows that a sufficient amount of SLs might permeate the skin barrier by using Arnica preparations to exert anti-inflammatory effects and that the topical use of plant preparations may be advantageous compared to the isolated compounds.

• https://pubmed.ncbi.nlm.nih.gov/25724362/ These results suggest that AM-2 and A. montana extract could be beneficial for use in hypopigmenting cosmetics as a consequence of their stimulatory effects on HSP70 expression.

• https://pubmed.ncbi.nlm.nih.gov/32956264/ Mud Pack With Menthol and Arnica Montana Accelerates Recovery Following a High-Volume Resistance Training Session for Lower Body in Trained Men

• Squalane Oil

• https://www.hindawi.com/journals/ija/2018/1829160/ In the skin, it has the capacity to absorb up to a quarter of its weight in oxygen, an important factor that prevents the development of cutaneous flora and peroxidase forms that lead to the development of skin diseases, acne, comedogenics, and wrinkles

  Squalane is a natural antioxidant molecule that protects cells from oxidative damage by exposure to ultraviolet light and other external sources; this molecule participates as a defense mechanism for the internal and external tissues of the skin in the human body.

  Given the characteristics of SQ as a natural emollient, it is considered an important component in the formulation of cosmetics and moisturizing agents for skin protection. It is a compound of efficient absorption on the surface of the skin, restoring it without leaving oily residues.

  The SQ is a natural constituent of the skin, which has a moisturizing effect that counteracts the appearance of wrinkles and burns through the fixation of water molecules on the surface of the skin.

• https://pubmed.ncbi.nlm.nih.gov/22361190/#:~:text=Several studies exhibited results that,models and in vitro environments. Several studies exhibited results that prove certain bioactivities for squalene and squalane. Up to date, anticancer, antioxidant, drug carrier, detoxifier, skin hydrating, and emollient activities of these substances have been reported both in animal models and in vitro environments

• SEABUCKTHORN BERRY OIL

• https://pubmed.ncbi.nlm.nih.gov/35890075/ The STLs and the AT possess a very high in vitro activity against both Leishmania species with median effective concentrations (EC50) ranging from 1.9 to 5.9 μg/mL. The AT was not cytotoxic for human tissue macrophages, skin fibroblasts, and hepatic cells. The therapeutic response of hamsters infected with L. braziliensis to the topical treatment with AT was 87.5% at a dose of 19.2 μg STL/2× day/60 d, 72.7% at doses of 19.2 μg STL/1× d/60 d and 67% at a dose of 38.4 μg STL/2× d/60 d. In turn, the therapeutic response in hamsters infected with L. tropica was 100% when treated at a dose of 19.2 μg STL/2× day/60 d and 71% at a dose of 38.4 μg STL/2× d/60 d. On the other hand, the effectiveness of treatment with glucantime administered intralesionally at a dose of 200 mg/every three days for 30 days was 62.5% for L. braziliensis and 37.5% for L. tropica infection. These results are promising and encourage the implementation of clinical trials with AT in CL patients as a first step to using AT as a drug against CL.Sea Buckthorn (Hippophae Rhamnoides)

• https://pubmed.ncbi.nlm.nih.gov/31228942/ Conclusion: The beneficial properties of fatty acids have been undervalued for several years. In contraposition, new studies reveal that fatty acids have an essential role for human health. The composition of fatty acids found in sea buckthorn (Hippophae rhamnoides) oil is unique for this species, presenting a vast range of health benefits for humans and therefore it is highly valued by both biomedicine and the cosmetic industry.

• https://pubmed.ncbi.nlm.nih.gov/21963559/ Conclusion: Sea buckthorn has been scientifically analyzed and many of its traditional uses have been established using several biochemical and pharmacological studies. Various pharmacological activities such as cytoprotective, anti-stress, immunomodulatory, hepatoprotective, radioprotective, anti-atherogenic, anti-tumor, anti-microbial and tissue regeneration have been reported.

• https://pubmed.ncbi.nlm.nih.gov/33017636/

  Conclusion: Phytochemical studies reveal the presence of a wide variety of compounds like flavonoids, carotenoids, polyunsaturated fatty acids, minerals, vitamins, Omega 3, 6, 9 and rarest Omega 7 and about 190 bioactive compounds. The pharmacological studies demonstrated, sea buckthorn to exhibit antibacterial, anti-sebum, antifungal, anti-psoriasis, anti-atopic dermatitis and wound healing activities. Besides, it has also been included in various cosmeceuticals for its use in skin-eventone, smoothening, rejuvenation, removal of wrinkles, scars, and pigmentation, and also in hair related problems.

  Pharmacological evaluation confirmed the ethnomedically claimed biological actions and other beneficial effects on the skin of H. rhamnoides using scientifically accepted protocols and controls. Its full application in the dermatology may be attributed to the presence of a variety of flavonoids, vitamins, and unsaturated fatty acids.

• https://pubmed.ncbi.nlm.nih.gov/24007892/ Conclusion: In conclusion, SBT seed oil has significant wound healing activity in full-thickness burns and split-thickness harvested wounds.

• https://pubmed.ncbi.nlm.nih.gov/22641502/ Conclusion: These results suggest that SFB has potential as a protective and therapeutic drug candidate against skin aging that functions by regulating the moisture content, MMP expression levels and SOD activity.

• https://pubmed.ncbi.nlm.nih.gov/34439527/ Conclusion: Sea buckthorn shows antimicrobial and antiviral properties, and is a potential nutraceutical or cosmeceutical. It was proven to help treat cardiovascular disease, tumors, and diabetes, as well as gastrointestinal and skin problems. The numerous health benefits of sea buckthorn make it a good candidate for incorporation into novel food products.

• https://pubmed.ncbi.nlm.nih.gov/28873377/

  Conclusion: These results suggest that Sea Buckthorn (SBT) oil had a beneficial effect on AD-like skin lesions, partially via inhibition of the Th2 chemokines TARC and MDC in inflamed skin.

• https://pubmed.ncbi.nlm.nih.gov/32638495/ Conclusion: Unsaturated fatty acid-enriched extract from Hippophae rhamnoides seed reduces skin dryness through up-regulating aquaporins 3 and hyaluronan synthetases 2 expressions

• https://pubmed.ncbi.nlm.nih.gov/32466930/ Conclusion: The exceptional value of sea buckthorn can be seen in the presence of both lipophilic antioxidants (mainly carotenoids and tocopherols) and hydrophilic antioxidants (flavonoids, tannins, phenolic acids, ascorbic acid) in remarkably high quantities. Some of the main nutrients, especially lipids of advantageous fatty acid composition, contribute to nutritional benefits of sea buckthorn products for a consumer as well.

• https://pubmed.ncbi.nlm.nih.gov/32600016/ Conclusion: The pronounced antioxidant and antibacterial properties of sea buckthorn products indicate the importance of sea buckthorn application in health promotion.

• https://pubmed.ncbi.nlm.nih.gov/25362595/ Conclusion: The statistical analysis revealed formulation with 5% plant extract was superior compared to placebo (base formulation) as formulation with extract have shown extremely significant improvements in skin hydration (p=0.0003) and TEWL (p=0.0087) throughout treatment course. Moreover, a significant (p<0.05) correlation between the active formulation and the improvement of the skin barrier functions was observed. The active formulation found to be superior to that of placebo.

• https://pubmed.ncbi.nlm.nih.gov/16633732/ Conclusion: The sea buckthorn flavone promoted the wound healing activity as indicated by improved rate of wound contraction, decreased time taken for epithelialization (16.3 days versus 24.8 days in controls) and significant increase in hydroxyproline (26.0%) and hexosamine (30.0%) content. These findings were also confirmed by histopathological examinations. In addition, it was observed that sea buckthorn flavone possesses potent antioxidant properties as evidenced by significant increase in reduced glutathione (55.0%), vitamin C (70.0%) and catalase (20.0%) activities in wound granulation tissue. The flavone treatment also resulted in significant decrease in lipid peroxide levels (39.0%). The results suggest that the sea buckthorn flavone promotes wound healing activity.

• https://pubmed.ncbi.nlm.nih.gov/30142919/ Conclusion: Sea buckthorn oil partially prevents UV-induced ROS generation and enhances the level of non-enzymatic antioxidants such as glutathione (GSH), thioredoxin (Trx) and vitamins E and A. Moreover, it stimulates the activity of Nrf2 leading to enhanced antioxidant enzyme activity. As a result, decreases in lipid peroxidation products (4-hydroxynonenal, 8-isoprostaglandin) and increases in the endocannabinoid receptor levels were observed. Moreover, sea buckthorn oil treatment enhanced the level of phospholipid and free fatty acids, while simultaneously decreasing the cannabinoid receptor expression in UV irradiated keratinocytes and fibroblasts. The main differences in sea buckthorn oil on various skin cell types was observed in the case of PPARs-in keratinocytes following UV radiation PPAR expression was decreased by sea buckthorn oil treatment, while in fibroblasts the reverse effect was observed, indicating an anti-inflammatory effect. With these results, sea buckthorn seed oil exhibited prevention of UV-induced disturbances in redox balance as well as lipid metabolism in skin fibroblasts and keratinocytes, which indicates it is a promising natural compound in skin photo-protection.

• https://pubmed.ncbi.nlm.nih.gov/35306042/ Conclusions: Exerted the effects of anti-inflammation and repairing skin barrier by regulating Th1/Th2 balance. This finding indicates that TFH is a novel potential agent for the external treatment of AD.

• https://pubmed.ncbi.nlm.nih.gov/8667579/ Conclusion: The markedly expressed stimulating effect on the healing process is explained with the rich content of vitamins (A, C, E etc.) and microelements (sulfur, selenium, zinc, copper etc.) in the extract used.

• https://pubmed.ncbi.nlm.nih.gov/19330185/ Conclusion: Hippophae rhamnoides L**.** increased significantly blood flow of the wound region (P<0.05). It can be used for the treatment of skin wound healing, preferably than dexpanthenol.

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162715/ Conclusion: In summary, sea buckthorn oil significantly stimulates the antioxidant system in keratinocytes and fibroblasts. Therefore, sea-buckthorn seed oil prevents UV-induced impair in redox systems as well as lipid metabolism disorders in skin fibroblasts and keratinocytes, which makes it a promising natural substance in skin photo-protection.

• https://pubmed.ncbi.nlm.nih.gov/34712136/ Conclusion: A Fatty Acid Fraction Purified From Sea Buckthorn Seed Oil Has Regenerative Properties on Normal Skin Cells tested for cytotoxicity, cytokine and growth factor production, and regenerative effect on normal keratinocytes and skin fibroblasts. Evidence is presented that the palmitic acid enriched fraction was a suitable sea buckthorn seed oil derived product with cell proliferation properties on both skin cell types.

• https://pubmed.ncbi.nlm.nih.gov/31680964/ Conclusion: , significant reduction in ear epidermal thickness and skin lesion scores was observed with SBKT. In conclusion, SBKT showed anti-inflammatory and anti-psoriasis-like efficacies in healing chemical-induced inflammation and psoriasis. The possible mode of action of SBKT was found through inhibition of reactive nitrogen species, and downregulation of NF-κB protein and pro-inflammatory cytokines. Thus, the present data suggest that Sea buckthorn oil can be used as an anti-inflammatory and anti-psoriatic nutraceutical.

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822464/ Conclusion: These findings suggest that H rhamnoides L. can contribute to survival of random pattern skin flaps in a dose-dependent way. These effects may be related to blockage of the oxidative enzymes. In addition, this extract may have a role as an enzyme coactivator against the free oxygen radicals produced in membranes and lipoprotein particles and are crucial in preventing lipid peroxidation (24,25). The clinical relevance and experimental findings presented here support the idea that this agent could be used easily in every flap operation.

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776824/ Conclusion: In view of the results obtained it can be suggested that extracts from H. rhamnoides L. could serve as a non-toxic source of beneficial compounds for a food supplement and cosmetics.

• https://pubmed.ncbi.nlm.nih.gov/15911921/ Conclusion: Statistically significantly augmented the healing process, as evidenced by increases in the content of hydroxyproline and protein as well as the reduction in wound area when compared with similar effects in response to treatment using povidone-iodine ointment (standard care). The reduced glutathione, vitamin C, superoxide dismutase, catalase, and glutathione peroxidase activities showed significant increases in seabuckthorn leaf extract-treated wounds as compared to controls. The lipid peroxide levels were significantly decreased in leaf extract-treated wounds. The results suggest that aqueous leaf extract of seabuckthorn promotes wound healing, which may be due to increased antioxidant levels in the granulation tissue.

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818504/ Conclusion: Unsaturated fatty acid‐enriched extract from Hippophae rhamnoides seed reduces skin dryness through up‐regulating aquaporins 3 and hyaluronan synthetases 2 expressions

• https://pubmed.ncbi.nlm.nih.gov/21814424/ Conclusion: The in vitro results showed a good stability over 4 weeks of observation period of both the Base and Formulation and the Formulation has anti sebum secretion effects over 8 weeks of observation period.

• https://pubmed.ncbi.nlm.nih.gov/17131913/ Conclusion: Protective effect of ethanolic and water extracts of sea buckthorn (Hippophae rhamnoides L.) against the toxic effects of mustard gas

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797847/ Conclusion: In conclusion, SBKT showed anti-inflammatory and anti-psoriasis-like efficacies in healing chemical-induced inflammation and psoriasis. The possible mode of action of SBKT was found through inhibition of reactive nitrogen species, and downregulation of NF-κB protein and pro-inflammatory cytokines. Thus, the present data suggest that Sea buckthorn oil can be used as an anti-inflammatory and anti-psoriatic nutraceutical.

• Sunflower (Helianthus anuus seed oil)

  • https://pubmed.ncbi.nlm.nih.gov/22995032/ Sunflower seed oil preserved stratum corneum integrity, did not cause erythema, and improved hydration in the same volunteers.

  • https://pubmed.ncbi.nlm.nih.gov/30548578/ Topical emollients, particularly sunflower seed oil, appear to reduce the incidence of skin infections.

  • https://pubmed.ncbi.nlm.nih.gov/32994929/ The health benefits of sunflower include blood pressure and diabetic control, skin protection, and lowering cholesterol and other functions.

  • https://pubmed.ncbi.nlm.nih.gov/36409190/ Sunflower Oil is harmless to the skin of neonates and can be used to maintain their skin integrity.

  • https://pubmed.ncbi.nlm.nih.gov/20199440/ As PPAR-alpha agonists have been shown to stimulate keratinocyte differentiation, improve barrier function, and enhance lipid metabolism in the skin, it has been suggested that SOD might also be efficacious in atopic dermatitis (AD). An initial clinical evaluation of the care effect of a 2% SOD emulsion in 20 adult volunteers with atopic skin revealed the moisturizing properties of SOD. Finally, a strong steroid-sparing effect and a positive effect on quality-of-life parameters were clearly demonstrated for the 2% SOD cream in studies in infants and babies with AD.

    Raspberry Seed Oil

  • https://pubmed.ncbi.nlm.nih.gov/31975502/

    Conclusion: Skin color, elasticity, and radiance were significantly improved. The smoothness, scaliness, and wrinkles were also revealed significant improvement. The vitamin C, vitamin E, and raspberry leaf cell culture extract serum has anti-aging and brightening effects of skin.

  • BEESWAX

  • https://pubmed.ncbi.nlm.nih.gov/36999457/

    Conclusion: Several studies show the benefits of topical beeswax in supporting the skin barrier.

  • https://pubmed.ncbi.nlm.nih.gov/15022655/

    Conclusion: 8/10 patients with dermatitis showed significant improvement after 2 weeks.

• Hemp (CBD)

  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778347/ We demonstrate here for the first time that CBG in a clinical study is both safe and effective in promoting skin health by reducing the appearance of redness and improving barrier function better than a placebo. CBG exhibits a broad range of in vitro activity, including antioxidant, anti-inflammatory, anti-acne, and anti-aging properties. Based on the data reported here, CBG is an attractive new candidate for dermatological use, outperforming its more well-known derivative, CBD. Lastly, utilizing our novel yeast fermentation technology platform, we can produce CBG and other minor cannabinoids with higher purity using a more sustainable and cost-effective process compared to C. sativa plant extraction and chemical synthesis. (Arnica Montana)

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736837/ Hemp is proven to help with a wide variety of skin disorders and health including acne, wrinkles, wound healing, moisturization, inflammatory issues and more.

  • https://pubmed.ncbi.nlm.nih.gov/34785006/ In vitro and in vivo studies of Cannabis have suggested it has favorable effects on regulating pain, pruritus, and inflammation, making it a potentially attractive therapeutic agent for many dermatologic conditions. Use in skin cancer, acne, psoriasis, pruritus, dermatitis, scleroderma, dermatomyositis, cutaneous lupus erythematous, epidermolysis bullosa, pain, and wound healing.

  • https://pubmed.ncbi.nlm.nih.gov/35695447/ Together with the discovery of the cannabinoid receptors on the skin, it has been further illustrated that topical cannabis has anti-inflammatory, anti-itching, analgesics, wound healing and anti-proliferative effects on the skin.

  • https://pubmed.ncbi.nlm.nih.gov/33335413/ In particular, cannabidiol (CBD), a non-psychoactive compound from the cannabis plant, has garnered significant attention in recent years for its anecdotal therapeutic potential for various pathologies, including skin and cosmetic disorders.

  • https://pubmed.ncbi.nlm.nih.gov/33851375/ Phytocannabinoids have demonstrated several beneficial properties at the cutaneous (skin) level. These properties include anti-inflammatory, antioxidant, anti-aging, and anti-acne effects. These effects are mediated through various mechanisms, both dependent and independent of cannabinoid receptors (CB1 and CB2).

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913911/ In addition to the previously known antioxidant properties of the tested extracts, which can have a positive effect on the structure and condition of skin cells, this work also shows other benefits of hemp extracts. The abilities of inhibiting matrix metalloproteinases, collagenase and elastase, presented for the first time in this work, as well as proven antioxidant properties make these extracts valuable ingredients for the production of a wide range of products that can be used in the treatment and care of the skin. Due to the high demand for preparations that inhibit the aging processes of the skin, the effect of hemp extracts on skin hydration and the possibility of preventing the degradation of collagen and elastin fibers presented here indicates the value of these extracts. The lack of a negative effect on the metabolic activity and viability of skin cells indicate the legitimacy of including hemp extracts in the recipes of skin care cosmetics as well as medicinal preparations.

  • https://pubmed.ncbi.nlm.nih.gov/33557174/ The obtained results indicate that hemp extracts can be a valuable source of biologically active substances that reduce oxidative stress, inhibit skin aging processes and positively affect the viability of skin cells. The analysis also showed that hydrogels based on cannabis extracts have a positive effect on skin hydration.

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878527/ The discovery of a skin endocannabinoid system and its role in maintaining skin homeostasis, alongside the anti-inflammatory actions of cannabinoids, has raised interest in their use for the treatment of skin inflammatory diseases, which is the focus of this review

  • https://chat.openai.com/?model=gpt-4-browsing A polycaprolactone (PCL) patch was developed to study the long-term release of hemp seed oil on a skin model and on human skin. It was found that up to 55% of the oil was released within 6 hours, and the moisturization of the volunteers’ skin increased by around 25%

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210160/ there is overwhelming clinical evidence suggesting the beneficial effects of topical cannabinoids in treating a myriad of skin conditions.

    A topical endocanabinnoids-containing emollient provided an average of an 86% reduction in subjective pruritus. In a 3-week open-label study involving 21 patients with uremic pruritus, a topical application of endocanabinnoids-containing cream twice a day for three weeks resulted in total elimination of pruritus in more than 38% of the subjects, and another 52% of them reported significantly reduced pruritus.

  • https://pubmed.ncbi.nlm.nih.gov/34363728/ Human clinical studies suggest that cannabinoids may be used in eczema, acne, pruritus, and systemic sclerosis treatment. Cannabidiol (CBD) may enhance hair growth via multiple mechanisms.

  • https://pubmed.ncbi.nlm.nih.gov/30142706/ After conducting our analysis, we found that cannabinoid products have the potential to treat a variety of skin conditions, including acne vulgaris, allergic contact dermatitis, asteatotic dermatitis, atopic dermatitis, hidradenitis suppurativa, Kaposi sarcoma, pruritus, psoriasis, skin cancer, and the cutaneous manifestations of systemic sclerosis.

  • https://pubmed.ncbi.nlm.nih.gov/31599175/ The authors reviewed the literature on the pharmacology and use of cannabinoids in treating a variety of skin conditions including acne, atopic dermatitis, psoriasis, skin cancer, pruritus, and pain. Cannabinoids have demonstrated anti-inflammatory, antipruritic, anti-ageing, and antimalignancy properties by various mechanisms including interacting with the newly found endocannabinoid system of the skin thereby providing a promising alternative to traditional treatments.

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917174/

  1. CBG, which is a substance from a plant, stopped the growth of Staphylococci bacteria really well when used in high amounts (about 96-97% stopped). It also reduced the growth of E. coli and P. aeruginosa bacteria, but not as much as Staphylococci. When used in a medium amount (about half of the high amount), it stopped about 57-63% of these bacteria.

  2. CBD, another substance from the same plant, didn't work as well against Staphylococci as CBG did. It only stopped about 41% of these bacteria. However, it worked better against E. coli and P. aeruginosa, stopping about 79% and 73% of them at the highest amount.

  3. They also tested ethanol, which is a type of alcohol, as a control. Ethanol didn't work very well against Staphylococci (only about 9-22% stopped), but it did stop about 40% of P. aeruginosa.

  4. The important thing is that CBG and CBD worked better than ethanol against these bacteria, especially at the highest amount used.

  Important for:

  1. Acne Prevention: Staphylococci and other bacteria can contribute to the development of acne when they colonize hair follicles and pores on the skin. By inhibiting biofilm formation, CBG and CBD may help reduce the proliferation of these bacteria, potentially contributing to a reduction in acne breakouts.

  2. Skin Health: Biofilms formed by bacteria can compromise the skin's natural defenses and contribute to various skin issues, including infections, irritations, and inflammation. Inhibiting biofilm formation may support overall skin health by reducing the risk of these problems.

  3. Anti-Inflammatory Effects: Some studies suggest that cannabinoids like CBD have anti-inflammatory properties, which could benefit the skin by reducing redness, swelling, and discomfort associated with inflammatory skin conditions like acne, eczema, or psoriasis.

  4. Skin Aging: Chronic inflammation and oxidative stress can accelerate skin aging. By reducing inflammation and acting as antioxidants, CBG and CBD may help protect the skin from premature aging, promoting a more youthful and vibrant complexion.

  • https://pubmed.ncbi.nlm.nih.gov/30993303/ the results showed that topical treatment with CBD-enriched ointment significantly improved the skin parameters, the symptoms and also the PASI index score. No irritant or allergic reactions were documented during the period treatment.

  • https://pubmed.ncbi.nlm.nih.gov/34577578/ Cannabidiol Application Increases Cutaneous Aquaporin-3 and Exerts a Skin Moisturizing Effect

  • https://pubmed.ncbi.nlm.nih.gov/35056807/ CBG serum showed statistically significant improvement above placebo for transepidermal water loss (TEWL) and reduction in the appearance of redness. Altogether, CBG's broad range of in vitro and clinical skin health-promoting activities demonstrates its strong potential as a safe, effective ingredient for topical use and suggests there are areas where it may be more effective than CBD.